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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik JURNAL ILMU BUDAYA Jurnal Kimia Terapan Indonesia Edumaspul: Jurnal Pendidikan Jurnal Ilmu dan Teknologi Kayu Tropis JURNAL ILMU KEFARMASIAN INDONESIA Pharma Xplore : Jurnal Sains dan Ilmu Farmasi EduPsyCouns: Journal of Education, Psychology and Counseling Jurnal Media Akuntansi (MEDIASI) Makara Journal of Science
Muhammad Hanafi
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Journal : Makara Journal of Science

 1 
Identification and Bioactivity Studies of Flavonoid Compounds from Macaranga hispida (Blume) Mull.Arg Megawati,; Saepudin, Endang; Hanafi, Muhammad; Darmawan, Akhmad; Lotulung, Puspa Dewi N.
Makara Journal of Science Vol. 19, No. 3
Publisher : UI Scholars Hub

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Abstract

Two flavonoid compounds, 5,7,3’,4’-tetrahydroxy-6-geranylflavonol (1) and kaempferol 7-O-β-glucose (2) have been isolated from the leaves of Macaranga hispida (Blume), Mull.Arg. Isolation and purification were conducted by chromatography methods and chemical structure characterization was carried out by spectroscopic methods. The 5,7,3’,4’-tetrahydrxyi-6-geranyl flavonol (1) and kaempferol 7-O-glucose (2) had moderate cytotoxic activity against murine leukemia P-388 cell lines with IC50 value of 0.22 and 101.5 μg/mL, respectively. The IC50 for antioxidant activities of (1) and (2) were 2.83 and 13.95 μg/mL, respectively. The LC50 of (1) and (2) from BSLT were 350 and >1000 μg/mL, respectively.
Co-Authors . Hariyanti Akhmad Darmawan Andi Sadapotto Andi Sadapotto Andri Eko Putra Atiek Soemiati Atiek Sumiati B. Suwandl Berna Elya D Efrina Dadan Ridwanuloh Endang Saepudin, Endang Evawani Elysa Lubis Fadlina Chany Saputri Fatmawaty Fatmawaty Fauzi Febrianto Hasan Hasan Herry Cahyana Ibrahim manda Iis Irawatty Dewi Ika Mustika Ilhamuddin Ilhamuddin Intan Nurjaya Kurnia Sofyan Lababa Lababa Lotulung, Puspa Dewi N. Mamoru Kanzaki Megawati, Ngadiman Ngadiman Nina Artanti Nova Yohana Nurmala Nurmala Nurmala Nurmala Nurul Fadhilah Suardi Puspa D.N Lotulung Renhart Jemi Rina Hidayati Pratiwi Rita K Sari Rita Kartika Sari Rosa Dewi Pratiwi Rosmalena Rosmalena Sam Hermansyah Santy Rahmawati Shibata Kozo Sofa Fajriah Soleh Kosela Sri Mursiti Suminar A Achmadi Suminar S Achmadi Suminar S Achmadi Syahrul Aiman Syamsu T Teni Ernawati Usman M Vinella Winata Vivitri Dewi Prasasty Wasrin Syafii dan Kurnia Sofyan Gustan Pari Buchari Yanotama T Laksana Yasir ", Yasir Yesi Desmiaty, Yesi